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Hemp Seeds- 10 oz

Hemp Seeds are high in healthy omega 6s (LA & GLA) needed to balance hormones, boost metabolism and lower inflammation. Hemp Seeds are also the highest plant-based protein and contain 10 grams of protein in just 3 tablespoons. Hemp Seeds are a healthier and more affordable alternative to processed protein powders. Whether you are vegan, vegetarian, or looking to increase your protein needs, these super seeds provide an abundance of essential nutrients.

Daily Dosage: 3 Tablespoons

How To: Add to smoothies, trail mix, oatmeal or sprinkle on salad.

Hemp Seeds are high in healthy omega 6s (LA & GLA) needed to balance hormones, boost metabolism and lower inflammation. Hemp Seeds are also the highest plant-based protein and contain 10 grams of protein in just 3 tablespoons. Hemp Seeds are a healthier and more affordable alternative to processed protein powders.

The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis

Affiliations

  • 1 Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.
  • 2 Departement of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R. Iran.
  • 3 Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I.R. Iran.
  • 4 Department of Biochemistry, School of Medicine, Urmia University of Medical Science, Urmia, I.R. Iran.
  • PMID: 30607150
  • PMCID: PMC6288989
  • DOI: 10.4103/1735-5362.245964

Free PMC article

The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis

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Authors

Affiliations

  • 1 Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.
  • 2 Departement of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R. Iran.
  • 3 Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I.R. Iran.
  • 4 Department of Biochemistry, School of Medicine, Urmia University of Medical Science, Urmia, I.R. Iran.
  • PMID: 30607150
  • PMCID: PMC6288989
  • DOI: 10.4103/1735-5362.245964

Abstract

The mammalian target of rapamycin (mTOR) has a fundamental role in the metabolism, growth, and regulation of the immune system. The interferon gamma (IFN-γ)derived from T helper 1 (Th1) cells is a prominent pro-inflammatory cytokine in multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE). Due to the exclusive role of rapamycin (RAPA) in mTOR complex 1 (mTORC1) inhibition, essentially Th1 differentiation and IFN-γ production, we evaluated the potential therapeutic effects of hemp seed/evening primrose oils (HSO/EPO) in comparison with RAPA administration in EAE. To evaluate the therapeutic effects of EPO/HSO supplement in comparison with RAPA, EAE was induced using myelin oligodendrocyte glycoprotein (MOG) peptide and complete Freund’s adjuvant in C57BL/6 mice. The weight, clinical score, and histological findings were evaluated. Total mRNA was extracted from local lymph nodes and qRT-PCR was used for the purpose of the genes expression level of regulatory associated protein of TORC1 (RAPTOR) and IFN-γ. Our results indicated that the relative expression of RAPTOR and IFN-γ genes were significantly reduced in HSO/EPO, RAPA, and RAPA + HSO/EPO treated groups in comparison with the untreated group. Interestingly, histological findings have shown that the HSO/EPO treated group remarkably regenerated the myelin sheath, but this did not occur in the case of RAPA or combined RAPA and HSO/EPO treated groups. Our findings suggeste that HSO/HPO can be used as a potent immunomodulator and as a good candidate for re-myelination and downregulation of immune response for treatment of MS.

Keywords: Experimental autoimmune encephalomyelitis; Inflammation; Multiple sclerosis; Myelin sheath; Sirolimus.

Figures

Weighing of EAE animals in…

Weighing of EAE animals in comparison with naïve mice. Data presented as mean…

Clinical course of EAE in…

Clinical course of EAE in animals. Data presented as mean ± SEM. *…

Pathological analysis of brain sections.…

Pathological analysis of brain sections. Group A, RAPA + HSO/EPO-treated mice showed (A…

The fold changes in the…

The fold changes in the mRNA expression of mTORC1 and IFN-γ genes in…

The mammalian target of rapamycin (mTOR) has a fundamental role in the metabolism, growth, and regulation of the immune system. The interferon gamma (IFN-γ)derived from T helper 1 (Th1) cells is a prominent pro-inflammatory cytokine in multiple sclerosis (MS) and its animal model, the experimental a …