CBD Entourage Oil

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Entourage 10% high quality CBD oil organic and vegan. Enjoy the benefits of Entourage effect with full spectrum CBD oil Entourage 10%. The entourage effect describes unique synergy achieved by all cannabinoids and terpenes in the cannabis plant. What does the entourage effect mean for CBD users? This article will provide you with everything you need to know about the whole-plant concept. The therapeutic impact of this broad spectrum CBD oil blend is greater than the sum of its individual parts, creating "Entourage Effect". 2000mg of CBD isolate infused with therapeutic Copaiba and four other high terpene essential oils that interact synergistically to deliver a powerful broad spectrum CBD Supplem

ENTOURAGE 10% CBD OIL

Our 10% CBD Entourage oil preserves all the beneficial molecules of the plant, thanks to an exclusive process known as the “Low Temperature Process Extract”.

CBD NATUREIGHT OILS

Natureight oils are organic, 100% vegan and high-quality full spectrum CBD oils.

We combine ancient tradition with scientific advances to regain internal balance, alleviating more acute disorders and achieving the well-being of your body and mind.

All our CBD oils are full spectrum processed extracts. They are food supplement based on full hemp extract (Cannabis Sativa L.) that contains CBD (cannabidiol) naturally, a non-psychoactive cannabinoid. We offer diverse CBD concentrations to suit every need and maximize results.

THE NATURE, OUR BALANCE

Our hemp comes from seeds certified by the European Union. It is grown without pesticides, herbicides, growth hormones, chemical fertilizers, or additives of any kind. Natureight Full Spectrum CBD oil is subject to strict control at every stage, from cultivation to your home, to offer maximum quality and safety.

Ingredients

Bottle 10ml

  • Hemp extract (Cannabis sativa L.) : 4000mg
  • Organic hemp seed oil (Cannabis sativa L.) : 6000mg
  • Total CBD : 1000mg
  • mg CBD/drop: 4mg CBD

Our hemp extracts contain more than 140 cannabinoids, terpenes, flavonoids and other plant compounds useful for your health.

No colouring agents
No preservatives
No allergens

Instructions

  1. Check well before using
  2. Take half a dropper (0.5ml = 50mg CBD), Up to 70mg per day
  3. Hold the drops under the tongue minimum 30 seconds before swallowing
  • Store in a cool, dry place away from light
  • Do not exceed the recommended dosage
  • Do not use if pregnant or nursing
  • Food supplements cannot be used as a substitute for a varied and balanced diet

More information

According to studies published by NCBI (National Center for Biotechnology Information):

5 reviews for ENTOURAGE 10% CBD OIL

Mathias – 3 September, 2018

Bonjour, rien à redire sur le produit.
Je l’ai testé pour le SJSR : pas suffisamment efficace.

frgaborit – 17 October, 2018

Les douleurs de mon mari liées à l’algodystrophie ont considérablement diminuées après 8 jours de traitement. Il est ravi.

Hermal Delphine – 10 February, 2019

Je l’utilise depuis peu mais j’ai la sensation d’avoir plus d’énergie.. facile à prendre avec ce flacon..

Mafalda Alves – 1 May, 2019

o cbd ajudou muito um doente epiléptico a sair de um quadro de ponta de onda contínua do sono, que durava há anos.
Foi muito bom. É ótimo

Vânia Lopes (verified owner) – 25 June, 2021

A minha filha Carolina. É epilética e portadora de uma doença rara Cul4B ou Cabezas síndrome. A epilepsia dela melhorou e a parte comportamental também

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CBD Entourage Effect: What Is It & How It Works with Other Cannabinoids

The entourage effect is one of the most intriguing discoveries in recent times when it comes to cannabis plants and their compounds. Proponents of the entourage effect claim that extracts produced from the whole cannabis plant increase the efficacy of its health benefits — something that would be unachievable with isolated compounds.

Scientists have contradictory views on this concept. There are clear indications that full-spectrum cannabis extracts are more effective in certain cases than their isolated counterparts. The advocates of isolating specific compounds and standardizing dosages aren’t so positive about these findings, claiming that attributing the entourage effect to all situations is a far-reaching generalization.

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A full-spectrum product in the world of cannabis includes cannabinoids — even traces of THC — terpenes, and other compounds. There are also broad-spectrum extracts and isolates. The broad-spectrum is like a “light” version of full-spectrum because it contains all the aforementioned substances except for THC. Isolates, in turn, refers to pure cannabinoids that have been separated from the remaining constituents of cannabis. These are flavorless and odorless products that are sold in powders or infused into different items.

In this article, we’ll focus specifically on the entourage effect; this will be the most detailed yet to-the-point guide you’ll ever read, so even when you’re done with the text, save it for later and share it with friends to increase their awareness about different CBD spectra.

What Makes Cannabinoids and Terpenes So Special?

Cannabinoids and terpenes are the active ingredients of cannabis that work synergistically to amplify the health benefits of each other. Cannabis researchers call it “the entourage effect.”

The debate has usually revolved around THC vs CBD, and comparing which one is better. But in fact, we should look at them as complementary compounds that can help you get the most out of your cannabis use.

Believe it or not, there’s a whole lot going on in the plant on a molecular level.

But how does one decode the term “entourage effect?” What is the role of the other 113 cannabinoids and 200 terpenes?

Find your answers in the next section.

What is the Entourage Effect in CBD?

In very simple terms, the entourage effect helps maximize the health benefits of CBD oil. It occurs when all the compounds within the cannabis plant interact with our bodies, producing stronger effects than they would if a person took them in isolation. These stronger effects are referred to as a “synergy.”

The entourage effect was first mentioned by two scientists in 1998 — Raphael Mechoulam and Shimon Ben-Shabat. They suggested that the endocannabinoid system (ECS) manifested “the entourage effect.” (1) According to the authors of the study, various “inactive” compounds and related molecules enhanced the activity of the major endogenous cannabinoids: 2-AG and anandamide. Mechoulam and Ben-Shabat said their discovery made it clear why botanical medications were often more effective than synthetic isolates.

For CBD oil users, it means that CBD isn’t the only compound responsible for the health benefits you experience. If you feel stronger relief from the stress of physical discomfort using a full-spectrum CBD oil, this may be caused by the synergistic effects provided by other cannabinoids, such as CBD, CBDV, CBG, CBC, or CBN, and terpenes such as beta-caryophyllene, limonene, myrcene, or linalool.

While CBD is a powerful compound on its own, it needs a team of supporters to develop its full potential.

Terpenes are fascinating molecules, and we’re going to devote an entire section to them, but before we make it there, let’s take a look at the most well-known entourage effect between CBD and THC.

THC & CBD: The Most Well-Known Cannabis Entourage Effect

One of the first observed and most cited entourage effects is the relationship between CBD and THC.

While THC, the cannabinoid that gets you high, binds directly to the CB1 cannabinoid receptors in the brain, CBD uses different mechanisms to manifest its effects. When you take these two compounds together, CBD reduces THC’s psychotic potential by blocking the sites of the CB1 receptors to which THC tries to bind. As a result, you feel less high than you would if you consumed THC alone.

The evidence supporting CBD’s ability to help take the edge off THC is piling up. In the 1980s, the Food and Drug Administration (FDA), approved a synthetic form of THC known as Marinol. While the medication did a decent job of increasing patients’ appetite, it also had side effects such as paranoia. Another FDA-approved drug, Sativex, contains both CBD and THC in a 1:1 ratio, so patients can tolerate it without getting too stoned.

Once you understand the interaction between CBD, THC, and the CB1 receptor, you should get a general idea of how the entourage effect works.

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THC is the agonist of this receptor, meaning it works like a key that unlocks the receptor’s lock. CBD isn’t a direct agonist of the CB1 receptor, but it competes with THC for its space. As mentioned, taking these two compounds together leaves fewer receptors for THC to activate. In this scenario, the potential side-effects of THC, such as anxiety and paranoia, are modulated.

Adie Wilson-Poe, a professor at Washington University (St. Louis) says that CBD uses a minimum of 14 different mechanisms of action in the central nervous system alone. Aside from that, it has over 65 molecular targets. CBD acts through a myriad of pathways, so it’s hard to link its health benefits solely to CB1 occupation.

Now, when you take full-spectrum CBD oil, there are a lot more compounds entering your body. Using full-spectrum products activates legions of beneficial molecules at the same time.

Benefits of THC-Only Products

Please note that we cannot make any health claims regarding cannabis compounds. We always encourage you to do your own research and explore the world of cannabinoids and terpenes. Below we only share information about the potential benefits of THC-only and CBD-only products.fg

The benefits of THC include:

  • Deep relaxation
  • Relief from stress
  • Reduced discomfort and stiffness
  • Regulation of the sleep cycle
  • Modulation of the gut microbiome
  • Improved appetite

THC effects usually reach their peak when you consume an edible. When you eat a cannabis brownie, for example, THC gets metabolized in the liver, transforming into 11-hydroxy-THC. This metabolite is five times stronger than THC. So, when you smoke cannabis and take 10 mg of THC, it enters your lungs and goes to the bloodstream through the lung tissue. A 10 mg THC edible translates to 50 mg of THC when it comes to its potency.

Benefits of CBD-Only Products

CBD has very different effects from THC. The most vivid example is the lack of intoxication. It is the compound of choice for those who don’t tolerate THC well or are afraid of failing a drug test. Cannabidiol is also great for general supplementation because it supports the proper functioning of the endocannabinoid system.

CBD is mostly used to relieve:

  • Stress
  • Sleep deprivation
  • Psychosis
  • Physical discomfort
  • Tiredness
  • Endocannabinoid deficiencies

CBD also has a strong affinity with the immune system, regulating communication between immune cells and improving its performance.

What Happens When You Start to Use Whole-Plant Products?

The modulation of the psychoactive effects of THC is a significant benefit of the entourage effect, but the whole-plant concept is about more than that. Full-spectrum products can improve the overall efficacy of cannabinoids. The main reason why this is a new discovery is the lack of research regarding the health benefits of cannabis due to its prohibition. The minor cannabinoids, as well as terpenes, have many positive effects of their own, but it’s difficult to gauge the efficacy of certain entourage effects with different ratios of these compounds.

From our perspective, it’s rather a matter of the entourage effect making everything better rather than isolates being less effective — as far as preliminary research shows.

Evidence of the Entourage Effect

There’s a lot of science to support the higher efficacy of full-spectrum CBD. In 2011, Ethan Russo, one of the most esteemed cannabis researchers, published an important study in the British Journal of Pharmacology (2). In the study, Russo wrote that cannabinoids and terpenes produce synergistic effects that translate to better therapeutic effects.

Russo also conducted a more recent study published in the journal Frontiers in Plant Science in 2019 (3). He reviewed multiple studies that investigated the case for the Entourage effect. Russo concluded that there is strong evidence to suggest that the phytochemical factory in cannabis is more beneficial for humans than isolates.

In contrast, a study by Santiago et al., published in Biorxiv in 2019, claimed that there is no such thing as the entourage effect (4). The authors of the study analyzed the responses of cells transfected with human cannabinoid receptors (CB1 and CB2) in the presence of THC and a few selected terpenes.

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The authors found that the receptors were not altered by any of these compounds, whether they coexisted together or were used in separation. However, the authors also admitted limitations to their research. The main concern was the fact that the team only focused on a single CB1 and CB2 pathway.

What Are Terpenes?

Most people think about fragrances and flavors in herbs when they hear the word “terpenes.”

However, the research conducted over the last few years have shown that terpenes are potent therapeutic molecules. That’s because they are responsible for starting the entourage effect in the cannabis plant.

Terpenes are volatile aromatic substances that evaporate easily and provide plants, fruits, vegetables, and spices with their unique aromas. The more aromatic the plant, the more terpenes are in it.

If you’ve ever wondered why cannabis strains smell differently but still have some characteristics similar to other plants — the answer is “terpenes.”

So far, we know about 200 terpenes in cannabis, but only a few of them occur in concentrations large enough to be worth mentioning.

Terpenes can be broken down into three groups:

  • Monoterpenes
  • Diterpenes
  • Sesquiterpenes

Whether a specific terpene falls into one of these categories depends on the number of repeating units of a 5 carbon molecule known as isoprene, the structural marker of all terpenes.

10 Most Commonly Found Terpenes in Cannabis

As mentioned earlier, only a few terpenes are found in amounts substantial enough to mention them in this text:

Here are the 10 most commonly found terpenes in the cannabis plant:

  1. Myrcene
  2. Linalool
  3. Pinene
  4. Limonene
  5. Beta-Caryophyllene
  6. Humulene
  7. Eucalyptol
  8. Delta-3-Carene
  9. Borneol
  10. Terpineol

Health Benefits of Terpenes

It is true that terpenes influence the aromas of plants, but there’s a growing body of evidence that they have a plethora of health benefits — especially when consumed along with cannabinoids such as CBD.

The list of potential health benefits of terpenes include:

  • Reduced stress
  • Appetite control
  • Relief from physical discomfort
  • Cognitive boost
  • Better blood circulation
  • Modulation of nausea and vomiting
  • Protection of healthy cells
  • Sedation

Needless to say, these effects are stronger when put together in a cannabis extract such as full-spectrum CBD oil.

Final Thoughts on the Entourage Effect

The entourage effect has garnered a lot of attention recently. If this concept is true for all cannabis extracts, it may change the way people use hemp and marijuana-based products forever. However, the existence of this phenomenon doesn’t necessarily mean that broad-spectrum CBD or CBD isolate is inferior to full-spectrum products. There are cases where the entourage effect isn’t the desired effect.

Nevertheless, the concept that cannabinoids and terpenes are more powerful together than on their own is an intriguing one. In an interesting video, Dr. Sean McAllister evaluates the effects of THC and CBD on tumor growth. He suggests that using the two cannabinoids on cancerous cells in the lab leads to faster death of malignant cells while protecting the healthy ones.

The real challenge faced by scientists is to find out how we can possibly leverage the entourage effect by manipulating the ratios of cannabinoids and terpenes. When we get a deeper understanding of this phenomenon, we could adjust different forms of CBD to specific needs. Now that’s what we call personalized science!

CBD Entourage 2000

2000mg of CBD isolate infused with therapeutic Copaiba and four other high terpene essential oils that interact synergistically to deliver a powerful broad spectrum CBD Supplement.

With more than 40 organic compounds in this blend, CBD and Beta-Caryophyllene are the heavy hitters. The Beta-Caryophyllene found in Copaiba has been known to enhance the potency and effectiveness of natural oils when used in conjunction.

Our 100% pure CBD and Essential Oils in this blend create one of the most powerful and effective CBD supplement on the market today!

Ingredients

Medium Chain Triglyceride (MCT) Oil, CBD Isolate Extract, Essential Oils of: Copaiba, Lemon, Orange, Mandarin, Clove

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